Nanonized progesterone formulation for improved oral bioavailability in healthy and pregnant rabbits
نویسندگان
چکیده
The aim of this study is to evaluate and compare the oral bioavailability nanonized progesterone (nano-PG) micronized (micro-PG) sustained release tablet formulation in healthy pregnant rabbits. High pressure compressed gas technology reduces particle size from 1.72 ± 2.5 μm 800 35 nm (nano-PG). DSC XRD showed that both micro-PG nano-PG were crystalline exist as form I. Higher melting enthalpy indicated improved drug stability whereas slight reduction degree crystallanity following nanonization. Nano-PG demonstrated 2-fold higher solubility SDS aqueous solution significantly permeability (p < 0.05) across porcine intestine compared micro-PG. pharmacokinetics was conducted Cmax rabbits however difference significant only. 30% 18% rabbits, respectively. In conclusion, nanonization improves solubility, dissolution PG without affecting solid state characters.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2022
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2022.13.s09.157